Fig 1.
Flow diagram of study selection procedure.
Table 1.
Basic characteristics of the included studies.
Table 2.
Basic characteristics of the included studies.
Fig 2.
Forest plot of Hazard ratio (HR) for the association between Interleukin-8 and overall survival(OS).
A. HRs with corresponding 95% CIs of Interleukin-8 expression with OS. B. HRs with corresponding 95% CIs of Interleukin-8 expression in stage IV colorectal cancer patients with OS. C. Subgroup analysis of HRs with corresponding 95% CIs of serum source Interleukin-8 expression with OS. HR>1 implied worse survival for the group.
Fig 3.
Forest plot of Odds ratio (OR) for the association between Interleukin-8 and clinicopathological features.
A. ORs with corresponding 95% CIs of Interleukin-8 expression with UICC stage. B. ORs with corresponding 95% CIs of Interleukin-8 expression with lymphatic metastasis. C. ORs with corresponding 95% CIs of Interleukin-8 expression with liver metastasis. OR>1 implied significant correlations between IL-8 and advanced stage, lymphatic metastasis, and liver metastasis.
Fig 4.
The Summary receiver operating characteristic (SROC) curve of Interleukin-8 for detecting colorectal cancer.
The AUC is 0.92.
Table 3.
Diagnostic parameters of IL-8 for detecting colorectal cancer.
Table 4.
Sensitivity analysis of IL-8 for diagnostic evaluation.