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Fig 1.

Flow diagram of literature search and study selection.

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Table 1.

Characteristics of Included Systematic Reviews/Meta-analyses.

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Table 2.

Characteristics of Primary Studies.

Non-Pharmacological Interventions for Delirium Prevention in Surgical Setting.

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Table 3.

Elements of the multicomponent non-pharmacological interventions across primary studies.

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Fig 2.

Risk of Bias of Primary Studies of Multicomponent Non-Pharmacological Interventions for Prevention and Treatment of Delirium.

✔low risk of bias? unclear risk of bias X high risk of bias; RCT, Randomized Controlled Trial; CCT, Controlled Clinical Trial; BAS before-after studies (*) post-acute skilled nursing facilities.

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Table 4.

GRADE quality of evidence summary table for the comparisons of multicomponent non-pharmacological interventions with usual care for delirium prevention or treatment.

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Fig 3.

Forest plot of risk ratios comparing multicomponent non-pharmacological interventions vs usual care for delirium prevention in older patients in surgical setting.

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Table 5.

Characteristics of Primary Studies—Non-Pharmacological Interventions for Delirium Prevention in Medical Setting.

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Fig 4.

Forest plot of risk ratios comparing multicomponent non-pharmacological interventions vs usual care for delirium prevention in older patients in medical setting.

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Table 6.

Characteristics of Included Primary Studies—Non-Pharmacological Interventions for Delirium Treatment.

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Table 7.

Characteristics of Included Primary Studies—Single-Component Based Non-Pharmacological Intervention for Delirium Prevention.

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Fig 5.

Risk of Bias of Primary Studies of Single Non-Pharmacological Interventions for Prevention of Delirium.

✔low risk of bias? unclear risk of bias X high risk of bias; RCT, Randomized Controlled Trial; CCT, Controlled Clinical Trial; BAS before-after studies; (*) Geriatric Risk Assessment MedGuide software.

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Fig 5 Expand

Table 8.

GRADE quality of evidence summary table for the comparisons of single component non-pharmacological interventions with usual care for delirium prevention.

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Table 8 Expand