Fig 1.
Overall plasma TTV DNA kinetics post-transplantation.
Forty-six lung transplant recipients were regularly monitored for plasma TTV DNA load during the first three months post-transplantation with a mean sampling interval of 12.2 days. The individual TTV DNA measurements (n = 320) are represented as filled circles and the computed non-linear regression line of best-fit is shown.
Fig 2.
Individual TTV DNA increase kinetics post-transplantation in relation to the pre-transplant TTV level.
(A) Individual plasma TTV DNA load increase kinetics after lung transplantation and initiation of immunosuppressive therapy are shown for two lung transplant patients. The individual TTV DNA measurements are represented as filled circles. (B, C) The relationship between the patients’ pre-transplant TTV DNA load and the TTV DNA doubling time over the first 30 days post-transplantation (B), or the patients’ peak TTV DNA level (C) is shown. Correlation analyses were performed by Spearman’s rank test. Tx, transplantation; LTRs, lung transplant recipients.
Fig 3.
Development of TTV DNA load up to day 15 post-transplantation.
(A) Change in log10 TTV DNA load from pre-transplant TTV load to day 15 (± 3 days) post-transplantation in plasma of 22 lung transplant recipients. (B) Relationship between pre-transplant TTV load and the change in TTV DNA load up to day 15 analyzed by Spearman’s rank test. LTRs, lung transplant recipients.