Table 1.
Enrolment criteria.
Fig 1.
The primary endpoint in this study is the change in St. George’s Respiratory Questionnaire (SGRQ) [19] at 360 days post final treatment. A change of four points is widely accepted to be the minimally clinically important difference (MCID).[20] Pulmonary function tests including whole body plethysmography were performed as per international guidelines using the European Community of Coal and Steel Workers’ cohort normal values.[21] The 6 minute walk distance (6MWD) was performed according to ATS guidelines.[22] These assessments were performed at each non-treatment visit.
Table 2.
Baseline characteristics.
Fig 2.
Efficacy outcomes in the coil treated patients 90, 180 and 360 days post final treatment.
Table 3.
Efficacy outcomes in coil treated patients 90, 180 and 360 days after final treatment as compared to baseline.
Table 4.
Investigator reported respiratory serious adverse events.