Fig 1.
Analysis of cluster partitions obtained with CNM (circles) and infomap (empty squares) methodologies.
The panel shows the cumulative cluster-size function as a function of lint. Symbol sizes were set using a scale proportional to the log-size of the corresponding cluster. Reddish filled circles were used for the 8 largest CNM communities. The horizontal line corresponds to the 10% accumulated mass level. Dashed vertical lines delimit a region of values of the order square root of total number of links in the network, [√L/2, √2L], corresponding to the natural scale found to operate in modularity optimization procedures [25, 30].
Fig 2.
The Biological Homogeneity Index, BHI, estimated for each of the 8 CNM largest communities, is depicted as red points (CNM clusters are ordered according decreasing size).
Green triangles show the BHI level of the infomap partition of clusters included in the respective CNM structure. For each CNM community, boxplots depict main features of BHI distributions estimated for an ensemble of 1000 random shuffling realizations of the corresponding infomap labels. Noticeably, the mean BHI values of the randomized partitions agree with the BHI level obtained for the corresponding structure-less CNM clusters (red points).
Fig 3.
Distributions of PIN nodes in the Z-P plane obtained when the CNM and infomap clusterization were considered are shown in left and right panels respectively.
A color-coded kernel density estimation was also depicted in the figures. Dashed lines in the figure delineate regions corresponding to the seven different universal roles.
Table 1.
Summary of Fisher statistical association test between the ARG set and cartographic role assignments.
Fig 4.
ROC curves for ARG genes based on node’s infomap-participation, CNM-participation, degree, bridge-centrality and betweenness feature levels are shown as solid black, orange dashed, blue dotted-dashed, dotted-dashed red and green dashed lines respectively.
Only nodes with mid/low connectivities (i.e. network nodes with degree values lower than the 90% percentile of the entire degree distribution) were considered. The horizontal dotted line depicts the maximum sensitivity level achieved infomap-kinless ARG gene with the lowest infomap-participation value.