Table 1.
Baseline Hemodynamics.
Fig 1.
Panel A and B shows representative traces depicting the effect of propofol on MAP in control and TRPA1-/- mice. Panel C depicts summarized data depicting the effect of propofol on MAP in control (n = 26), TRPA1-/- (n = 12), TRPV1-/- (n = 12) and TRPAV-/- mice (n = 12). Data are means ± SEM * = P<0.05 vs. baseline. # P<0.05 vs. control.
Fig 2.
Propofol induced changes in MAP in Control and TRPV1-/- mice: Panels A and B: Summarized data depicting the effect of L-NAME (100 mg/kg/min) on propofol-induced changes in MAP in control and TRPV1-/- mice.
Panels C and D: Summarized data depicting the effect of Pen A (50 ug/kg/min) on propofol-induced changes in MAP in control and TRPV1-/- mice. Panels E and F: Summarized data depicting the effect of L-NAME and Pen A in combination on propofol-induced changes in MAP in control and TRPV1-/- mice. Data are means ± SEM. *P<0.05 compared to baseline. #P<0.05 compared to control. n = 6 mice in each group.
Fig 3.
Propofol induced changes in MAP in TRPA1-/- and TRPAV-/- mice: Panels A and B: Summarized data depicting the effect of L-NAME (100 mg/kg/min) on propofol-induced changes in MAP in TRPA1-/- and TRPAV-/- mice.
Panels C and D: Summarized data depicting the effect of Pen A (50ug/kg/min) on propofol-induced changes in MAP in TRPA1-/- and TRPAV-/- mice. Panels E and F: Summarized data depicting the effect of L-NAME and Pen A in combination on propofol-induced changes in MAP in control and TRPA1-/- and TRPAV-/- mice. Data are means ± SEM. *P<0.05 compared to baseline. n = 6 mice in each group.
Fig 4.
A schematic representation showing the proposed mechanisms by which propofol causes vasodepressor responses in-vivo.