Fig 1.
Flow diagram of the process (and the reasons) of selecting and excluding studies for this meta-analysis.
Table 1.
Characteristics of the included trials.
Fig 2.
Methodological quality graph and summary of the included studies.
Fig 3.
Meta-analysis of TBIL and ALT levels.
(A) Meta-analysis of TBIL levels based on the study by P. L. Nicastri. (B) Meta-analysis of TBIL levels based on the studies by Huang Jinyang and V. V. Stelmakh. (C) Meta-analysis of TBIL levels based on the studies by Qin Bo and Zhu Shishu. (D) Meta-analysis of ALT levels based on the study by P. L. Nicastri. (E) Meta-analysis of ALT levels based on the studies by Qin Bo and T. Binder. (F) Meta-analysis of ALT levels based on the studies by Qin Bo and Huang Jinyang.
Table 2.
Data and comparisons regarding the included parameters.
Fig 4.
Data analysis and synthesis of the AST levels, pruritus scores and numbers of adverse events based on respective baselines or data types.
(A) Meta-analysis of AST levels based on the studies by Qin Bo and Zhu Shishu. (B) Meta-analysis of pruritus scores in the subgroup analysis. (C) Meta-analysis of adverse events for SAMe compared with placebos. (D) Meta-analysis of adverse events in an additional analysis.
Table 3.
Related data and comparisons for additional analysis.