Table 1.
Patient Characteristics.
Fig 1.
Time-related differences among groups of prostate cancer patients with different BMIs who received weekly docetaxel treatment or other docetaxel regimens.
Box plots are shown for the following parameters: A) age at diagnosis of prostate cancer, B) age at initiation of docetaxel treatment, C) the number of years after diagnosis of prostate cancer when docetaxel treatment was initiated, and D) the number of months of follow-up starting from the initiation of docetaxel therapy. The black line inside each box represents the median, and outliers are represented by circles beyond the whiskers. The patient groups are as labeled beneath the horizontal axes. The groups that received weekly docetaxel regimens are shown in white, and those received other regimens are shown in red. The blue lines with P values labeled next to each indicate significant (P < 0.05) intergroup comparisons. The P values were based on non-parametric one-way ANOVA (Kruskal-Wallis) with post-hoc intergroup comparisons using the Tukey test.
Fig 2.
Correlations among body composition parameters and among docetaxel dosage calculations.
A) A matrix of scatter plots for body composition parameters is shown. The frequency distribution of each body composition parameter is presented as labeled at the diagonal of the matrix. B) A correlation matrix of the body composition parameters is shown. The sizes of the dots indicate the magnitude of the correlation, and the dots are color coded for the correlation coefficient according to the scale on the right. The correlation coefficients are reported in the corresponding boxes reflected across the diagonal. C) A matrix of scatter plots for dosages calculated based on body composition parameters is shown. The frequency distribution of each parameter is presented as labeled at the diagonal of the matrix. D) A correlation matrix of the dosages is shown in a manner similar to that for B. E) The probability density function, estimated by kernel density estimation, of the proportion of the initial docetaxel dose relative to the reference dose for the weekly regimens (red solid line) and for the other regimens (green dashed line). The blue vertical dotted line represents a 10% reduction of the initial docetaxel dosage relative to the respective reference dosage for the groups as labeled. F) A parallel coordinates plot is drawn to demonstrate the relationships among covariates such as the type of docetaxel regimen, the dose of docetaxel in milligrams, and docetaxel dosages calculated based on body composition parameters. The patients with empirical reduction of the initial docetaxel dosage based on mg/m2 BSA by ≥10% are represented by green lines, and those otherwise are represented by brown lines.
Fig 3.
Overall survival of metastatic prostate cancer patients starting docetaxel treatment.
A) Univariate Kaplan-Meier survival functions for overall survival starting from the initiation of docetaxel treatment to the event of death are shown for patients in different BMI categories as labeled. Each + represents a censored data point. B) Univariate Kaplan-Meier survival functions for overall survival are shown for all patients in the study cohort grouped by VSR (upper left). Stratified by BMI categories (<25, 25–30, and >30 kg/m2 for the lower left, upper right, and lower right subpanels, respectively), the survival functions for patients in each BMI category are shown for the different VSR groups as labeled. Each + represents a censored data point.
Fig 4.
Overall survival of metastatic prostate cancer patients starting docetaxel treatment.
A) Univariate Kaplan-Meier survival functions for overall survival starting from the initiation of docetaxel treatment to the event of death are shown for all the patients in the study cohort grouped by docetaxel regimen (upper left subpanel). Stratified by BMI categories (<25, 25–30, and >30 kg/m2 for the lower left, upper right, and lower right subpanels, respectively), the survival functions for patients in each BMI category are shown for the different docetaxel regimens as labeled. Each + represents a censored data point. B) Survival functions of overall survival are shown, in a manner similar to that shown in A, as grouped by reduction of the initial docetaxel dosage relative to the reference dose.
Table 2.
Cox regression model for time between docetaxel initiation and death.