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Table 1.

Sequence of forward and reverse primers for real-time PCR.

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Fig 1.

Total cholesterol, cholesteryl esters and free cholesterol.

Plasma concentration of total cholesterol (Fig 1a), cholesteryl esters (Fig 1b) and free cholesterol (Fig 1c) in week 1 p.p., and before (week 0) and after (week 3) feed restriction in mid-lactation. Changes over time within the groups are marked with superscripts (A to C for the control group (CON); a to c for the feed-restricted group (RES); P < 0.05). Differences between control (CON) and feed-restricted (RES) group in week 3 are indicated by * (P < 0.05). Data are presented as means ± standard error of the mean.

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Fig 2.

VLDL-cholesterol, LDL-cholesterol and HDL-cholesterol.

Plasma concentration of VLDL-cholesterol (Fig 2a), LDL-cholesterol (Fig 2b) and HDL-cholesterol (Fig 2c) in week 1 p.p., and before (week 0) and after (week 3) feed restriction in mid-lactation. Changes over time within the groups are marked with superscripts (A to C for the control group (CON); a to c for the feed-restricted group (RES); P < 0.05). Differences between control (CON) and feed-restricted (RES) group in week 3 are indicated by * (P < 0.05). Data are presented as means ± standard error of the mean.

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Fig 2 Expand

Fig 3.

Phospholipids and TAG.

Plasma concentration of phospholipids (Fig 3a) and triacylgycerol (Fig 3b) in week 1 p.p., and before (week 0) and after (week 3) feed restriction in mid-lactation. Changes over time within the groups are marked with superscripts (A to C for the control group (CON); a to c for the feed-restricted group (RES); P < 0.05). Differences between control (CON) and feed-restricted (RES) group in week 3 are indicated by * (P < 0.05). Data are presented as means ± standard error of the mean.

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Fig 3 Expand

Fig 4.

LCAT and PLTP activities.

Plasma activity of lecithin:cholesterol acyltranserase (LCAT; Fig 4a) and phospholipid transfer protein (PLPT; Fig 4b) in week 1 p.p., and before (week 0) and after (week 3) feed restriction in mid-lactation. Changes over time within the groups are marked with superscripts (A and B for the control group (CON); a and b for the feed-restricted group (RES); P < 0.05). Data are presented as means ± standard error of the mean.

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Fig 4 Expand

Fig 5.

Milk cholesterol.

Cholesterol concentration (mmol/l) in milk (Fig 5a), cholesterol mass (grams) in milk (Fig 5b), cholesterol concentration in milk fat (mg cholesterol per 100 g fat; Fig 5c) and fat mass (grams) in milk (Fig 5d) in week 1 p.p., and before (week 0) and after (week 3) feed restriction in mid-lactation. Changes over time within the groups are marked with superscripts (A and B for the control group (CON); a and b for the feed-restricted group (RES); P < 0.05). Data are presented as means ± standard error of the mean.

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Fig 5 Expand

Table 2.

Relative mRNA abundances (delta CT, log2) of genes analyzed in liver biopsies in week 1 p.p., and before (week 0) and after (week 3) feed restriction in mid-lactation.

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Table 2 Expand