Fig 1.
Anatomic MR images for anaplastic gliomas with different ratios of enhancement to necrosis (≥ 2 and < 2).
The areas of contrast enhancement are marked in yellow; areas of central necrosis are marked in blue; areas of T2 hyperintensity (exclusion of contrast enhancement) are marked in green.
Table 1.
Characteristics of overall patients with anaplastic gliomas.
Fig 2.
Volumetric ratios of enhancement to necrosis in anaplastic gliomas with different VEGF expression levels.
(A) Ratio of enhancement volume to necrosis volume in the low VEGF expression group (LEG) and high VEGF expression group (HEG) (Mann-Whitney, p = 0.009). (B) Ratio of enhancement volume to T2 hyperintensity volume in the low VEGF expression group and high VEGF expression group (Mann-Whitney, p = 0.681). (C) The volumetric ratios of necrosis to T2 hyperintensity in the low VEGF expression group and high VEGF expression group were not significantly different (Mann-Whitney, p = 0.277).
Fig 3.
Kaplan-Meier estimates of survivals using volumetric ratio of enhancement to necrosis.
Log-rank analysis indicated (A) a significant PFS advantage (log-rank, p = 0.013) and (B) a significant OS advantage (log-rank, p = 0.001) for patients with anaplastic gliomas with a high volumetric ratio (≥ 2) of enhancement to necrosis.
Table 2.
Univariate analysis of survival outcomes.
Table 3.
Multivariate analysis of survival outcomes.