Table 1.
Characteristics of eligible studies in the meta-analysis of MTHFR 677C>T polymorphism and male infertility.
Table 2.
Quality assessment based on the Newcastle-Ottawa Scale of studies included in this meta-analysisa.
Fig 1.
Flow diagram of study selection.
Fig 2.
Forest plots of MTHFR 677C>T polymorphism and male infertility risk (CT+TT vs. CC).
[A for overall populations; B for ethnicity subgroup; C for sperm concentration subgroup; D for control sources subgroup]. The squares and horizontal lines correspond to the study-specific OR and 95% CI. The area of the squares reflects the study-specific weight (inverse of the variance). Diamonds represent the pooled OR and 95% CI. athe 37th reference, bthe 49th reference
Fig 3.
Funnel plot for publication bias of MTHFR 677C>T and infertility risk (CT+TT vs. CC) in overall populations.
The horizontal line in the funnel plot indicates the random-effects summary estimate. Sloping lines indicate the expected 95% CI for a given SE.
Table 3.
Characteristics and results of the present study compared with the former five meta-analyses.