Table 1.
Study population demographic and clinical features.
Table 2.
PCR and culture results.
Fig 1.
Study flow chart.
Fig 2.
Tuberculosis (TB) test results for specimens from HIV-positive and HIV-negative case and well-control children.
Data are analysed by assessment of probability of TB disease indicated by the Stegen-Toledo (ST) clinical score (see Methods). (A) TB PCR results. (B) Microscopy and culture test results: auramine microscopy, microscopic-observation drug-susceptibility (MODS) liquid culture, and Lowenstein Jensen solid culture.
Table 3.
PCR and culture results.
Fig 3.
Tuberculosis (TB) microscopy and culture test results for specimens from the 23 cases with culture-positive TB.
All subjects had two specimens of each type analyzed for TB by the methods shown. The graph shows the proportion (and the data table the number) of patients who had positive results in (A.) at least one of their two specimens and (B.) who had positive results in the first specimen of their two specimens, with separate bars indicating results for stool, nasopharyngeal aspirate (NPA) or gastric aspirate specimens tested only by auramine microscopy (smear), Lowenstein-Jensen (LJ) solid culture, or microscopic-observation drug-susceptibility (MODS) liquid culture [e.g. the first bar demonstrates that all 23 cases would have been diagnosed if only (1.) LJ and MODS culture had been performed (i.e. without microscopy) on (A.) duplicate gastric aspirate specimens].
Fig 4.
The number of tuberculosis (TB) microscopy and culture tests done for each case confirmed.
A. All cases had duplicate stool, nasopharyngeal aspirate (NPA) and gastric aspirate specimens tested for tuberculosis (TB) by auramine microscopy (smear), Lowenstein-Jensen (LJ) solid culture, and microscopic-observation drug-susceptibility (MODS) liquid culture [e.g. the left-most gray bar indicates that in this study 1458 tests (1. smear, LJ and MODS) were done (on A. stool, NPA and gastric aspirates) per HIV-positive case diagnosed; whereas the right-most black bar indicates that in this study if only (2.) smear and MODS testing had been done on only (B.) duplicate gastric aspirates then 42 tests would have been done per HIV-negative case diagnosed].