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Fig 1.

Study design and flow diagram.

1 High Risk for AKI—major surgery and one additional risk factor—critical illness, sepsis, major trauma, chronic renal disease or use of radiocontrast agent.2 AKI was defined according to KDIGO 2012 criteria by creatinine increase of > 0.3 after surgery.

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Fig 1 Expand

Fig 2.

Area under the curve (AUC) and the best cut-offs for predicting AKI, AKI Stage 2 and 3, early use of RRT and 28-days mortality.

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Fig 2 Expand

Table 1.

Patient characteristics (n = 107).

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Table 1 Expand

Table 2.

Baseline characteristics of the study subgroups.

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Table 2 Expand

Table 3.

Multivariable logistic regression model of perioperative parameters at the time of biomarker assessment with and without the (TIMP-2)*(IGFBP7) for risk assessment of AKI, AKI Stage 2 and 3, RRT and 28-day mortality.

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Table 3 Expand

Table 4.

Multivariable logistic regression model of bedside postoperative parameters at the time of biomarker assessment with and without the (TIMP-2)*(IGFBP7) for risk assessment of AKI, use of RRT, 28-days mortality and AKI 2,3.

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Table 4 Expand