Fig 1.
Normal and abnormal planar image of 123I-MIBG cardiac scintigraphy.
Fig 2.
Flow diagram of the eligible patients and the enrolling process of the study.
Table 1.
Clinical characteristics of the subjects.
Table 2.
Sensitivity and specificity of visual assessment in differentiating between probable DLB and probable AD.
Fig 3.
Individual values for the H/M ratio of 123I-MIBG uptake.
Significant reductions in early and delayed H/M ratios were observed in probable DLB compared with probable AD group of all cases, mild dementia cases (MMSE ≥ 22), and moderate/severe dementia cases (MMSE ≤ 21) (see text). Green lines indicate the mean value of H/M ratio. AD: Alzheimer’s disease; DLB: dementia with Lewy bodies.
Fig 4.
ROC curves for the detection of probable DLB from probable AD based on H/M ratio of each group.
The area under the ROC curve of the early H/M ratio was 0.805 (p < 0.001) for the all patients group, 0.901 (p < 0.0001) for the mild dementia group, and 0.732 (p = 0.001) for the moderate/severe dementia group, whereas that for the delayed H/M ratio was 0.817 (p < 0.001), 0.942 (p < 0.0001), and 0.747 (p = 0.007), respectively. ROC: receiver operating characteristic. AUC: area under the curve.
Table 3.
Sensitivity and specificity of H/M ratio in differentiating between probable DLB and probable AD.