Fig 1.
Study Selection Process and Reason for Exclusion of Studies.
Table 1.
Details of Studies Included in Review and Source of Mycobacterium tuberculosis Isolates.
Table 2.
Drug Susceptibility Testing (DST) Methods Employed in Publications.
Fig 2.
Heat map of Reviewed Studies that Evaluated gyrA Gene Mutations in Mtb.
Heat map of individual papers indicating the number of isolates and the region of the gyrA gene studied. The number of isolates testes ranges from 8 (light grey) to 227 (black). Red indicates that a mutation has been found.
Table 3.
Cumulative Frequencies of the Most Frequently Occurring Mutations within gyrA Gene among Mycobacterium tuberculosis Isolates Resistant to Fluoroquinolones.
Mutations are listed in order of descending frequency.
Table 4.
Cumulative Frequencies of the Most Frequently Occurring Mutations within gyrB Gene among Mycobacterium tuberculosis Isolates Resistant to Fluoroquinolones.
Mutations are listed in order of descending frequency.
Table 5.
Cumulative Frequencies of Selected Mutations within gyrA Gene among Mycobacterium tuberculosis Isolates by Country.