Fig 1.
A. Simplified metabolism of flurbiprofen in humans. B. FLB (R = H) and OHF (R = OH) acylglucuronides with positions of the glucuronic acid moiety.
Table 1.
CYP2C9 genotypes and respective measured and estimated metabolic ratios for flurbiprofen.
Fig 2.
Distribution of the metabolic ratio (MR; concentration of 4’-hydroxyflurbiprofen [OHF] divided by the concentration of flurbiprofen [FLB]) measured in urine 2 h after administration of flurbiprofen to 283 individuals. Histograms are shown for the entire study group and for the genotypes with more than one individual. One single individual with genotype CYP2C9*3/*3 showed an MR of 0.096 (highlighted by an arrow in the histogram). The dashed lines indicate the best estimates of model-derived MRs, together with the FLB dose adjustment in percent of wild type *1/*1 (= 100%).
Table 2.
Compound specific liquid chromatography/ mass spectrometry parameters for flurbiprofen (FLB), 4’-hydroxyflurbiprofen (OHF) and the respective deuterated internal standards FLB-d3 and OHF-d3.