Table 1.
Clinical and biochemical characteristics of patients with Cushing’s syndrome (CS) and controls.
Fig 1.
Correlation between mean telomere length and proportion of short telomeres (< 5kb) in the study population (r-0.917, p < 0.001).
Fig 2.
Mean telomere length according to different cardiovascular risk factors after adjustment for age in Cushing's syndrome patients.
Abbreviations: bp, base pairs; DLP dyslipidemia, HT hypertension, T2DM Type 2 diabetes mellitus; MetS, metabolic syndrome; abd.per., increased abdominal perimeter.* p<0.05
Fig 3.
Mean telomere length (A) and proportion of short telomeres (<5kb) (B) in patients with Cushing’s syndrome according to the presence or absence of dyslipidemia (*p < 0.05).
Abbreviations: bp base pairs; DLP dyslipidemia.
Fig 4.
Mean Telomere length in patients with CS with several CVR factors.
Dyslipidemic patients (n = 35) compared to those with normal lipids (n = 42); dyslipidemic and hypertensive patients (n = 21) compared to those who did not have both CVR factors (n = 56); patients with dyslipidemia, hypertension and obesity (n = 15) compared to those who did not have three CVR factors (n = 62). Abbreviations: DLP: dyslipidemia; HT: hypertension; bp: base pairs
Table 2.
Correlations of telomere length with lipid profile in patients with Cushing’s syndrome without statin treatment (n = 60).
Fig 5.
Correlations between C-reactive protein (expressed as logarithm) and telomere length (in base pairs = bp) in patients with Cushing’s syndrome (r-0.412, p 0.019).
Table 3.
Studies examining relationships between the telomere system and lipid related parameters.