Fig 1.
Representative sarcomas showing range and pattern of immunohistochemical staining for MET (A-H) and HGF (I-P). (A, B, I, J) staining intensity score = 0, (C, D, K, L) score = 1+, (E, F, G, M, N, O,) score = 2+, (H, P) score = 3+. (A, C, E, N) undifferentiated pleomorphic sarcomas, (B, D, F, G, K, M) angiosarcomas, (H) control cell line, (I, L, O) leiomyosarcomas, (J) dedifferentiated liposarcoma, (P) control tissue breast cancer.
Table 1.
Immunohistochemical expression scores of MET and HGF.
Table 2.
FISH results of MET positive cases.
Fig 2.
Fluorescence in situ hybridization for MET.
Representative sarcomas showing different categories for MET gene copy number variations (see text for explanation). MET gene is labeled in green, centromere 7 in orange. (A) MET negative clear cell sarcoma, (B) MET negative angiosarcoma, (C) low level copy number gain in a clear cell sarcoma, (D) intermediate level copy number gain in an undifferentiated pleomorphic sarcoma, (E, F) high level amplification in undifferentiated pleomorphic sarcomas.
Table 3.
Correlation between MET amplification status and MET protein expression.