Table 1.
Statistics for the discovery studies mean serum urate levels.
Table 2.
Loci significantly associated with serum urate within any BMI stratum analysed and mean effect sizes across strata.
Fig 1.
Mean effect across BMI strata of allelic substitutions at representative variants displaying genome-wide significant association with SU in at least one BMI stratum and displaying nominally significant difference in effect size across BMI strata.
Effect size is on standardised age-adjusted SU levels. Error bars indicate the standard errors of the mean effect estimates within a BMI category. Horizontal lines indicate nominally significant (p < 0.05) differences in mean effect sizes between BMI categories, ** indicates significance at the 1% level taking into account the multiple comparisons performed. Differences in mean effect sizes between BMI strata were tested pairwise using the classical z-test, and Pdiff denotes the 2-sided test corresponding P-value. Lean: BMI < 25 kg/m2, overweight: 25 ≤ BMI ≤ 30 kg/m2, obese: BMI > 30 kg/m2.
Fig 2.
Forest plots of effect sizes within BMI stratum for variants with the two most significant mean effect size differences between BMI stratum.
A. RBMS1-TANK locus and B. TSPYL5 locus. The overall inverse—variance-weighted mean effect per BMI stratum is calculated assuming fixed effect across studies and represented by a lozenge, associated P-value displayed as P. Measure of heterogeneity between studies is reported (I-squared) with associated P-value for significance (p). Pdiff is the test of difference in mean-effect size P-value. For study abbreviations and references, see S1 Table.
Table 3.
Most significant BMI x SNP interaction terms for urate GWAMA.