Table 1.
Clinical and demographic characteristics of the 531 bipolar disorder patients.
Table 2.
Genotype frequencies of the studied TLR2 and TLR4 polymorphisms for the 531 bipolar disorder patients.
Fig 1.
Representation of age at onset of bipolar disorder according to TLR2 genotype and reported childhood sexual abuse.
Mean ± standard deviation of bipolar disorder age at onset is represented according to Toll-like receptor 2 (TLR2) rs3804099 risk genotype carrier state and reported sexual abuse as defined by the Childhood Trauma Questionnaire (CTQSSA).
Fig 2.
Kaplan-Meier survival curve of age at onset of bipolar disorder.
Patients were stratified in four groups according to TLR2 (Toll-like receptor 2) rs3804099 TT risk genotype carrier state and reported childhood sexual abuse as defined by the Childhood Trauma Questionnaire (CTQSSA) and age at onset defined as a time-to-event variable in a Kaplan-Meier survival curve (p = 0.002; corrected p = 0.02).