Table 1.
Demographic and cognitive profile of cases, according to dementia status.
Table 2.
Frequency of diffuse and compact Aβ plaques in the cingulate gyrus, based on the CERAD protocol.
Fig 1.
Aβ plaque subtypes in the ageing brain.
Six distinct Aβ plaque subtypes were identified in the ageing cohort: (a) diffuse plaques with no associated astrocytes; (b) compact plaques (also known as classical or core plaques) with no associated astrocytes; (c) diffuse plaques with focal astrogliosis; (d) compact plaques with focal astrogliosis; (e) diffuse plaques with circumferential astrogliosis; (f) compact plaques with circumferential astrogliosis, as indicated by the arrow. Scale bar represents 50μm
Fig 2.
Astrogliosis remote from Aβ plaques, Aβ plaques in layer VI and regions of densest plaque burden.
Both (a) small and (b) large areas of astrogliosis were detected in regions remote from Aβ plaques, as indicated by the arrow. (c) Clusters of plaques with associated reactive astrocytes were frequently observed in the deep cortex (layer VI) near the white matter border (WM), distinct from (d) the areas of densest amyloid burden. Scale bar represents 50μm (a) and 100μm (b-d).
Table 3.
Association of Aβ plaque subtype in the area of densest Aβ burden with Braak stage, general cognition (MMSE), dementia status and possession of ApoEε4 allele.
Table 4.
Association of Aβ plaque subtype in the deep cortex (layer VI) with Braak stage, general cognition (MMSE), dementia status and possession of ApoEε4 allele.
Table 5.
Summary of the major Aβ plaque subtype associations with Braak stage, general cognition (MMSE) and possession of the ApoEε4 allele.