Fig 1.
Study schema of enrolled patients and their outcomes.
Table 1.
Clinical Characteristics of enrolled patients.
Table 2.
Antiviral therapy for the patients.
Fig 2.
Kaplan–Meier curve showing mortality in patients with HBV-related acute-on-chronic liver failure.
Table 3.
Main causes of death at 3 months after study enrollment.
Table 4.
Main complications in enrolled patients during 3-months follow up.
Table 5.
Comparison of baseline clinical characteristics between survivors and non-survivors.
Fig 3.
Receiver operating characteristic curves (ROC) for evaluating 3-months mortality in patients with HBV-related acute-on-chronic liver failure.
The area under ROC curve (95% CI) of the new PI, CTP, MELD and MELD-Na scoring systems were 0.86 (0.75–0.93), 0.63 (0.50–0.74), 0.79 (0.67–0.87) and 0.74 (0.63–0.84), respectively. MELD: The model for end-stage liver disease. MELD-Na: MELD with incorporation of sodium. CTP: Child-Turcotte-Pugh. PI: prognostic index
Table 6.
Comparison of baseline clinical characteristics between survivors and non-survivors who had a normal serum Cr.
Fig 4.
Receiver operating characteristic curves (ROC) for evaluating 3-month mortality in patients of HBV-related acute-on-chronic liver failure with normal levels of serum creatinine.
The area under ROC curve (95% CI) of the new PI, CTP, MELD and MELD-Na scoring systems were 0.93 (0.84–0.98), 0.66 (0.52–0.78), 0.77 (0.64–0.87) and 0.68 (0.54–0.80), respectively. MELD: The model for end-stage liver disease. MELD-Na: MELD with incorporation of sodium. CTP: Child-Turcotte-Pugh. PI: prognostic index
Table 7.
AUCs for ROC and cutoff value for predicting prognosis of HBV-ACLF patients with normal levels of serum Cr.
Fig 5.
Survival curve in relation to prognostic index (PI) at admission in patients of HBV-related acute-on-chronic liver failure with normal levels of serum Cr.
Dashed line represented the high-risk group (PI ≥ 3.91) and plain line represented the low-risk group (PI < 3.91). The survival rate in low risk group (PI < 3.91) was 94.3%, which was markedly higher than those in the high-risk group (PI ≥ 3.91) (17.4%, P < 0.001).