Fig 1.
Flow chart of study selection by using electronic database searches.
Table 1.
Main characteristics of the eligible studies sorted by 5 different serum biomarkers.
Table 2.
Diagnostic accuracy of CEA, Cyfra21–1, p53, SCC-Ag, and VEGF-C for EC.
Fig 2.
Forest plot of estimates of the diagnostic odds ratio (DOR) for CEA, Cyfra21–1, p53, and SCC-Ag in the diagnosis of EC.
Point estimates of the diagnostic odds ratio from each study are shown as solid circles. Error bars are 95% confidence intervals.
Fig 3.
Funnel plot for the assessment of potential bias in CEA, Cyfra21–1, p53 and SCC-Ag assays.
The funnel graph plots the DOR (diagnostic odds ratio) against the 1/root (effective sample size), the dotted line is the regression line.