Table 1.
Characteristics of patients with cardiac valve replacement.
Table 2.
Genotype and allelic frequencies of rs9923231, rs7294, rs1057910, rs2108622, rs699664 polymorphisms obtained in our population and in other references of Chinese.
Table 3.
Basic information of the cited references.
Table 4.
Baseline characteristics of patients with target INR (1.5–2.5).
Figure 1.
Relation between the maintenance dose and the tested genes.
Panel A–E: rs9923231 (Panel A), rs7294 (Panel B), rs1057910 (Panel C), rs2108622 (Panel D), rs699664 (Panel E). Each box indicates 25 to 75 percentile of values, and the horizontal lines represent the median value of maintenance dose. *: p < 0.05 at ANOVA test.
Figure 2.
Relation between the plasma concentration and the tested genes.
Panel A—E: rs9923231 (Panel A), rs7294 (Panel B), rs1057910 (Panel C), rs2108622 (Panel D), rs699664 (Panel E). Each box indicates 25 to 75 percentile of values, and the horizontal lines represent the median value of plasma concentration. *: p < 0.05 at ANOVA test.
Table 5.
The effects of rs9923231, rs7294, rs1057910, rs2108622, rs699664 on warfarin maintenance dose and plasma concentration.
Table 6.
The relationship between plasma concentration and maintenance dose in patients carrying polymorphism variants of rs1057910.
Table 7.
The relationship between plasma concentration and INR in patients carrying polymorphism variants of rs9923231, rs7294, rs2108622 and rs699664.