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Figure 1.

Flow diagram of the systematic search and study selection process.

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Table 1.

Characteristics and outcomes of the studies comparing compliance with once versus twice/thrice/four times daily antibiotic regimens.

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Table 2.

Characteristics and outcomes of the studies comparing compliance with twice versus /thrice/four times daily antibiotic regimens.

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Figure 2.

Forest plot depicting the risk ratios (RR) of compliance of patients receiving antibiotic treatment once-daily versus multiple times daily.

(Vertical line = “no difference” point between the two regimens. Squares = risk ratios; Diamonds = pooled risk ratios for all studies. Horizontal lines = 95% CI).

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Figure 3.

Forest plot depicting the risk ratios (RR) of compliance of patients receiving antibiotic treatment twice-daily versus thrice or four times daily.

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Figure 4.

Forest plot depicting the risk ratios (RR) of compliance of patients receiving an antibiotic once-daily versus the same antibiotic or antibiotic of the same class twice or thrice-daily.

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Figure 5.

Forest plot depicting the risk ratios (RR) of compliance of patients receiving an antibiotic twice-daily versus the same antibiotic or antibiotic of the same class thrice-daily.

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Figure 6.

Forest plot depicting the risk ratios (RR) of compliance of patients receiving an antibiotic once-daily versus an antibiotic of the same broad class thrice-daily.

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Figure 7.

Forest plot depicting the risk ratios (RR) of compliance of patients receiving an antibiotic once-daily versus an antibiotic of different class thrice or four times daily.

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