Table 1.
Patient Characteristics.
Figure 1.
Change of the tumor size in the 18 patients.
Figure 2.
Imaging data of No. 17 patient who had bilateral RCC with lung metastasis.
(A1) Before neoadjuvant therapy, maximum tumor diameter in right kidney was 7 cm, maximum tumor diameter in left kidney was 4 cm. (B1) Right lung metastasis diameter was 1.5 cm. (A2) After left partial nephrectomy and successive 90 days of neoadjuvant therapy, maximum tumor diameter in right kidney was reduced to 5.2cm. (B2) Right lung metastasis diameter was 1.0 cm. (A3) After 150 days of neoadjuvant therapy, maximum tumor diameter in right kidney was 4.6 cm. (B1) Right lung metastasis diameter was 0.5 cm.
Table 2.
RECIST assessment in the 18 RCC patients.
Table 3.
Treatment details of each patient.
Figure 3.
Change of the average tumor CT value in the 18 patients.
Figure 4.
Imaging data of No. 11 patient who had left RCC with renal hilar lymph node metastasis.
(A) Left kidney tumor and renal hilar lymph node metastasis before neo-adjuvant therapy. (B) After 86 days of neoadjuvant therapy, left kidney tumor downsized and renal hilar lymph node decreased, tumor partially necrotized. (C) Section of resected left kidney, showing partial tumor necrosis and fibrosis.
Figure 5.
Imaging data of No. 13 patient who had right RCC with tumor thrombus.
(A) Right RCC with IVC grade III tumor thrombus before neoadjuvant therapy. IVC was obliterated. (B) After 92 days of neoadjuvant therapy, IVC thrombus was down–graded to grade II, IVC was partially recanalized. (C) Resected right kidney and IVC tumor thrombus.
Figure 6.
Imaging data of No. 16 patient with obstructed inferior vena cava (ICV).
(A1) IVC tumor thrombus filled IVC before neo-adjuvant therapy. (A2) After 148 days of neo-adjuvant therapy, IVC thrombus was shortened and fibrotic. (B1) IVC thrombus reached right atrium before neo-adjuvant therapy. (B2) After 148 days of neoadjuvant therapy, IVC thrombus was shortened.
Figure 7.
The survival curve of the 18 cases.