Table 1.
Baseline Characteristics of Included Studies.
Figure 1.
Flow chart for the selection process of eligible publications.
Figure 2.
Forest plots from the fixed-effect meta-analysis of the efficacy of TILs on the NAC response stratified by infiltration locations (A) and different cutoff values (B).
The width of horizontal line represents 95% CI of the individual studies, and the grey boxes represent the weight of each study. The diamond represents the overall summary estimate. The unbroken vertical line was set at the null value (HR = 1.0). Abbreviations: LPBC, lymphocyte-predominant breast cancer; TILs, tumor infiltrating lymphocytes.
Figure 3.
Forest plots from the fixed-effect meta-analysis of the efficacy of TILs on the NAC response stratified by different subtypes.
The width of horizontal line represents 95% CI of the individual studies, and the grey boxes represent the weight of each study. The diamond represents the overall summary estimate. The unbroken vertical line was set at the null value (HR = 1.0). Abbreviations: TNBC, triple negative breast cancer; HER2, human epithelial growth factor receptor 2; ER, estrogen receptor.
Figure 4.
Forest plots from the random-effect meta-analysis of the efficacy of TILs on the NAC response stratified by infiltration locations in multivariate way.
The width of horizontal line represents 95% CI of the individual studies, and the grey boxes represent the weight of each study. The diamond represents the overall summary estimate. The unbroken vertical line was set at the null value (HR = 1.0).
Figure 5.
Forest plots from the fixed- or random-effect meta-analysis of the efficacy of TILs subset on NAC response in pre-treatment biopsy (A, B).
The width of horizontal line represents 95% CI of the individual studies, and the grey boxes represent the weight of each study. The diamond represents the overall summary estimate. The unbroken vertical line was set at the null value (HR = 1.0).
Figure 6.
Forest plots from the fixed-effect meta-analysis of the efficacy of TILs subset on NAC response in post-treatment breast tissue.
The width of horizontal line represents 95% CI of the individual studies, and the grey boxes represent the weight of each study. The diamond represents the overall summary estimate. The unbroken vertical line was set at the null value (HR = 1.0).
Figure 7.
Forest plots from the random-effect meta-analysis of the efficacy of TIL subset on NAC response in pre-treatment biopsy in multivariate way.
The width of horizontal line represents 95% CI of the individual studies, and the grey boxes represent the weight of each study. The diamond represents the overall summary estimate. The unbroken vertical line was set at the null value (HR = 1.0).
Table 2.
Sensitivity analysis of TILs and TILs subset.
Figure 8.
Funnel plot for publication bias in the pooled pCR analysis based on TIL status (A) and TILs subset before (B) treatment.