Table 1.
Country of origin, subtypes and specimens information for the seroconversion panels used in the study.
Fig 1.
A: Changes in antibody avidity as measured by LAg-Avidity EIA post-seroconversion for all 259 seroconversion panels.
For the purpose of these plots, midpoint of last negative and first positive dates for each panel was used as the seroconversion date to calculate days post-seroconversion (X-axis). B: Changes in avidity for 176 panels after exclusion of suboptimal panels as required by some methods. C: Changes in avidity as depicted for suboptimal panels that were excluded for some methods.
Table 2.
Summary of 7 different methods used for determination of mean duration of recent infection (MDRI, in days with 95% CI) at varying cutoffs on LAg-Avidity EIA with corresponding level of proportion false recent (PFR) classification.
Fig 2.
Mean duration of recency at cutoff ODn of 1.5 by subtype or geographic region as determined by bionomial regression method that uses all specimens without any exclusion criteria.
Closed diamonds represent MDRI for different subtypes and vertical lines represent upper and lower 95% CI. The horizontal line represents overall mean MDRI of 130 days.
Fig 3.
Close-up view of changes in avidity with overlap of MDRI at cutoffs of 1.0 to 2.0 as determined by binomial regression method.
The red lines represent 95% bounds around MDRI.