Table 1.
Sample characteristics.
Figure 1.
Reaction times: Mean reaction times and their standard deviation in the fMRI reward task.
**: pā¤0.001 in post hoc testing. *: p<0.005 in post hoc testing. HD: Huntington disease mutation carriers, CON: control subjects.
Table 2.
Reaction times of behavioural tasks after scanning.
Figure 2.
Comparison of structural grey matter images: decreased dorsal striatal volume in mutation carriers as compared to control subjects (*: p<0.001, uncorrected, number of voxels per cluster >20 for illustration purposes).
Glass brain figure shows regional specificity of the results. Bar graphs on the right side depict parameter estimates of structural MRI volume differences between HD subjects and healty controls obtained from the left striatal peak voxel (x/y/z = ā24/2/15) and the corresponding voxel on the right side (x/y/z = 24/2/15). HD: Huntington disease mutation carriers, CON: control subjects.
Figure 3.
A - Position of 3-dimensional, independent regions of interest (ROIs): ventral striatum and anterior insula/orbitofrontal cortex (AI/OFC).
B - Mean corrected parameter estimates of fMRI effect within right ventral striatum ROI: parameter estimates demonstrate increased differential effects of reward expectation in HD compared to the CON group as an expression of functional compensation. C - Linear contrast (slope) of parameter estimates of fMRI effects within right ventral striatum: mean and standard deviation of individual slopes in each group and significant (*: p<0.05) group difference. HD: Huntington disease mutation carriers, CON: control subjects.