Table 1.
Clinical and biological characteristics of P. falciparum-infected patients and asymptomatic carriers.
Figure 1.
Mean MA plot associated with the comparison of cerebral malaria (CM) with asymptomatic malaria (AM) (mean log ratio of expression versus mean log intensity).
Statistically significant data according to the Benjamini and Yekutieli P value correction are shown as red dots for up-regulated genes and green dots for down-regulated genes in CM-associated parasites.
Figure 2.
The expression level measured by quantitative rt-qPCR for arrays data confirmation.
PFB0106c and PF13_0003 transcripts were highly up-regulated (fold change> 6) in arrays of 3D7-Lib-Ring (R) versus 3D7-R and 3D7-Lib late trophozoïte (LT) versus 3D7-LT, respectively. PFD1235W, PF11_0521, PFA0015c, PFD0065w, and PF11_0454 transcripts were moderately up-regulated (fold change range [2.5-5]) in 3D7-LT versus 3D7Lib-LT, CM-LT versus AM-LT, CM-LT versus 3D7-LT, and 3D7-Lib-R versus 3D7-R, respectively. PFE1620C and PFL0030C transcripts were down-regulated (fold change range [4 to 0]) in CM-LT versus 3D7-LT.
Figure 3.
(A), transcription level of UPs A1, A3, B1, and (B), transcription level of DC 8, DC13 var genes in parasites from cerebral malaria (CM) and uncomplicated malaria (UM). The differential in transcription was compared between clinical groups by the Mann-Whitney U test. P-values are shown for each primer set.
Table 2.
Gene ontology term of differentially expressed genes.