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Figure 1.

Flow chart of the two patient groups for establishment of a spontaneous PMVSD closure prediction scoring system.

(VSD, ventricular septal defect; CHF, congestive heart failure).

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Table 1.

Number of patients with different follow up periods in derivation and validation cohort.

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Table 2.

Baseline characteristics (categorical variables) of 1873 patients in the derivation cohort.

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Table 3.

Baseline characteristics (continuous variables) of 1873 patients in the derivation cohort.

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Table 4.

Results of multivariate Cox regression analysis in the derivation cohort.

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Figure 2.

Plots show SC probabilities occurring within 1 year(□) and 3 years(○) among PMVSD patients in the derivative cohort, plotted against the scoring system.

The LOESS fit lines (the solid line for 1-year and the dashed line for 3-year) using 50% fit plots show the trend of SC probability against the score. (SC, spontaneous closure).

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Figure 3.

Comparison among PMVSD patients of high probability(△), intermediate probably(○) and low probability(□) occurring SC by Kaplan-Meier's method.

A: Probability of defect remaining open in the deviation cohort (p<0.001). B: Probability of defect remaining open in the validation cohort (p<0.001).

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Table 5.

Scoring system for prediction of spontaneous PMVSD closure.

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Table 6.

Probability of SC associated with each score.

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Table 7.

Estimated probabilities and observed SC rates in derivation and validation cohort according to score groups.

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