Table 1.
Baseline Characteristics of 382 Participants with Amnestic Mild Cognitive Impairment (MCI).
Table 2.
Factors Associated with Conversion from Amnestic MCI to AD*.
Figure 1.
Observed versus Predicted Conversion from Amnestic MCI to AD over 3 Years by Brief Clinical Index Point Score.
The solid line shows the proportion of subjects predicted to progress from amnestic mild cognitive impairment (MCI) to probable Alzheimer's disease (AD) over three years as function of their brief clinical index point score, while the dotted line shows the actual proportions that progressed at each point score value based on three-year Kaplan-Meier (KM) estimates. The vertical bars show the number of individuals at each point score value (right vertical axis).
Figure 2.
Proportion of Subjects with Amnestic MCI Who Converted to AD in Low, Medium and High Risk Groups.
Fourteen percent of subjects with low risk scores (upper line, 0–2 points, n = 124) progressed from amnestic MCI to AD over three years compared to 51% of those with moderate risk scores (middle line, 3–8 points, n = 223) and 91% of those with high risk scores (lower line, 9–16 points, n = 35).
Figure 3.
Comparison of the Full and Brief Clinical AD Prediction Indexes.
The predicted (solid lines) and observed (dashed lines) are shown as a function of risk score values based on the previously published full index (light grey lines) and brief clinical index (dark grey lines). Prognostic accuracy was significantly higher for the full index (optimism corrected Harrell's c, 0.74) than the brief clinical index (0.71). However, the plot shows good concordance between observed and predicted risk for both indices.