Figure 1.
CONSORT Flow Diagram.
Table 1.
Patient characteristics.
Figure 2.
Kaplan-Meier curve for overall survival in patients who had no prior treatment.
Figure 3.
Intra-day variation in A) lactic acid, B) alanine, C) catechol, and D) paraxanthine.
Figure 4.
Intra-day variation in paraxanthine.
A. In all patients. At 6:30 AM: 0.75×10−3 (95% CI, 0.28–2.7×10−3) in patients with cachexia vs. 3.61×10−3 (1.91–5.48×10−3) pg/ml in those without cachexia, p = 0.35; TNF-α: 7.1 (1.2 to 30.2) vs. 3.3 (1.2 to 30.0) pg/ml, p = 0.27; leptin: 2.4 (1.0 to 9.8) vs. 4.0 (2.0 to 9.9) ng/ml, p = 0.27, respectively. B. In male patients. IL-6: 15.2 (range, 2.6 to 23.4) in patients with cachexia vs. 9.4 (1.4 to 28.7) pg/ml in those without cachexia, p = 0.57; TNF-α: 12.4 (1.2 to 29.0) vs. 3.2 (1.4 to 28.6) pg/ml, p = 0.29; leptin: 2.3 (1.0 to 8.8) vs. 3.45 (2.0 to 2.8) ng/ml, p = 0.34, respectively.
Figure 5.
Serological markers between patients with cachexia and those without cachexia.
A. In all patients. IL-6: 13.8 (range, 2.6 to 23.4) in patients with cachexia vs. 6.8 (1.4 to 28.7) pg/ml in those without cachexia, p = 0.35; TNF-α: 7.1 (1.2 to 30.2) vs. 3.3 (1.2 to 30.0) pg/ml, p = 0.27; leptin: 2.4 (1.0 to 9.8) vs. 4.0 (2.0 to 9.9) ng/ml, p = 0.27, respectively. B. In male patients. IL-6: 15.2 (range, 2.6 to 23.4) in patients with cachexia vs. 9.4 (1.4 to 28.7) pg/ml in those without cachexia, p = 0.57; TNF-α: 12.4 (1.2 to 29.0) vs. 3.2 (1.4 to 28.6) pg/ml, p = 0.29; leptin: 2.3 (1.0 to 8.8) vs. 3.45 (2.0 to 2.8) ng/ml, p = 0.34, respectively.
Figure 6.
Intra-day variation in leptin.