Table 1.
Parameter inputs for a model-based analysis of potential HIV cure strategies.
Table 2.
Base case results of an analysis of hypothetical HIV cure strategies*.
Table 3.
Threshold which key parameters would need to reach for each type of HIV cure strategy to be cost-effective (ICER<$100,000/QALY gained) or cost-saving.
Figure 1.
Gene Therapy compared to standard of care ART.
The figure depicts the cost-effectiveness of Gene Therapy compared to standard of care ART as a function of the three influential parameters identified via the one-way sensitivity analysis in Table 3: cost, relapse rate, and efficacy. In each panel, the horizontal axis denotes efficacy while the vertical axis denotes the relapse rate. Inside each panel, the shading denotes the resultant cost-effectiveness finding, ranging from cost-saving (green), through cost-effective (with an ICER<$100,000/QALY, yellow), to not cost-effective (≥$100,000/QALY or more expensive and less effective than ART, red). ART: antiretroviral therapy; ICER: incremental cost-effectiveness ration; QALY: quality-adjusted life year.
Figure 2.
Chemotherapy compared to standard of care ART.
The figure depicts the cost-effectiveness of Chemotherapy compared to standard of care ART as a function of the three influential parameters identified via the one-way sensitivity analysis in Table 3: cost, relapse rate, and efficacy. In each panel, the horizontal axis denotes efficacy while the vertical axis denotes the relapse rate. Inside each panel, the shading denotes the resultant cost-effectiveness finding, ranging from cost-saving (green), through cost-effective (with an ICER<$100,000/QALY, yellow), to not cost-effective (≥$100,000/QALY or more expensive and less effective than ART, red). ART: antiretroviral therapy; ICER: incremental cost-effectiveness ration; QALY: quality-adjusted life year.
Figure 3.
Stem Cell Transplantation compared to standard of care ART.
The figure depicts the cost-effectiveness of Stem Cell Transplantation compared to standard of care ART as a function of the three influential parameters identified via the one-way sensitivity analysis in Table 3: cost, relapse rate, and efficacy. In each panel, the horizontal axis denotes efficacy while the vertical axis denotes the relapse rate. Inside each panel, the shading denotes the resultant cost-effectiveness finding, ranging from cost-saving (green), through cost-effective (with an ICER<$100,000/QALY, yellow), to not cost-effective (≥$100,000/QALY or more expensive and less effective than ART, red). Instances where the intervention is both less expensive and less effective than ART are denoted in blue, but most were not cost-effective because the ICER of ART was <$100,000/QALY compared to SCT. The plus sign indicates a strategy that had an ICER for ART compared to SCT >$100,000/QALY gained. ART: antiretroviral therapy; ICER: incremental cost-effectiveness ration; QALY: quality-adjusted life year.