Figure 1.
A 43-year-old female with biopsy proven GBM. On Gd enhanced T1-weighed image (A), GBM shows heterogeneous enhancement in the left basal ganglia. ADC maps were coregistered to Gd enhanced T1-weighted image. Whole tumor volume ROI (ROI1) was drawn along the tumor border for each consecutive slice of the coregistered image (B). Multiple circular ROIs (ROI2) were drawn on coregistered image (area = 10 mm2) (C). A single circular ROI (ROI3) was drawn on any solid area, avoiding necrosis (area = 20 mm2) in coregistered image (D).
Table 1.
Interobserver variability measured as intraclass correlation coefficient for different ROI protocols.
Table 2.
ADC variables for lymphoma and GBM using three different ROI methods.
Table 3.
Sensitivity and specificity of ADC variables for differentiating lymphoma from GBM using ROC.
Figure 2.
Box-and-whisker plots of representative ADC variables for lymphoma and GBM: mean ADC in ROI1 (A) and minimum ADC in ROI2 (B).
The central box represents the value from the lower to upper quartile. The middle line represents the median. The horizontal line extends from the minimum to the maximum value. An outside value are plotted with s square marker.