Figure 1.
ON-A Phylogenetic tree constructed in Splitstree ver. 4.
All 722 polymorphic sites were included. Phylogenetic tree was built using BioNJ algorithm and then filtered for parsimony-informative sites.
Table 1.
Demographic characteristics of ON-A TB cases.
Figure 2.
Transmission events of ON-A TB cases based on WGS information and epidemiologic analysis.
Colored solid circles represent TB isolates that are identical to the suspected primary case (0 SNPs). Open circles represent related cases, separated by black solid dots representing SNPs acquired over time. Triangles represent TB cases outside of the homeless/under-housed group. Isolates from the same TB patient are represented by circles with dots in their background: WT25-08 and WT26-08; NM2-01 and NM3-01; and NM17-08 and NM19-08. *Isolates that had more than one passage prior to WGS.
Figure 3.
Dendrogram of IS6110 RFLP showing the 15 kb deletion distribution.
Branches indicate the clusters with identical RFLP patterns. Colored squares represent each of the six sub-clusters identified by WGS. Information regarding the presence or absence of the 15 kb deletion for each isolate is shown as “deleted” or “intact”.
Table 2.
Genes present in the 15 kb deleted region.