Figure 1.
C57BL/6 mouse retina showing the reference points for SD-OCT and histological measurements.
Dotted circle – optic nerve head (ONH); black solid circle – 1 mm diameter central area surrounding the ONH; inferior, middle and superior reference points, each 200 µm apart, both to the left and the right of the ONH.
Figure 2.
Cross-sectional views of the C57BL/6 mouse retina by SD-OCT (left) and histology (right).
OS/IS/ELM, outer segment/inner segment/external limiting membrane; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL/GC, inner plexiform layer/ganglion cell; RNFL, retinal nerve fiber layer.
Table 1.
Mean SD-OCT and histology retinal thickness (in µm) for each study animal.
Table 2.
Mean (± SE) SD-OCT/histology retinal thickness and calculated ‘correlation constant’ for each retinal sublayer.
Table 3.
Correlation constant (SD-OCT/histology) for total and retinal sublayer thickness measurements in each animal.
Figure 3.
Association between mean SD-OCT and histological thickness with correlation constants >1.
Scatter plot points refer to all observations for outer nuclear layer and retinal nerve fiber layer.
Figure 4.
Association between mean SD-OCT and histological thickness with correlation constants <1.
Scatter plot points refer to all observations for outer segment/inner segment/external limiting membrane, outer plexiform layer, inner nuclear layer, inner plexiform/ganglion cell layers, and total retinal thickness.
Table 4.
Comparison of SD-OCT/histology ‘correlation constant’ between present and prior studies.