Figure 1.
Histogram of the distribution of the Tac C/D ratio (ng/mL*1/mg).
The patients showed a symmetric distribution relating to their C/D ratio and were categorized in three groups: slow, intermediate and fast metabolizers. Intermediate metabolizers were grouped around the mean C/D ratio value (1.05–1.54). Patients showing a C/D ratio <1.05 were defined as fast metabolizers, ≥1.55 as slow metabolizers.
Table 1.
Patients characteristics.
Table 2.
Medication doses and blood trough concentrations.
Figure 2.
eGFR value comparison between the three metabolism groups (a).
Fast and intermediate Tac metabolizers showed statistically noticeable lower eGFR values compared to slow metabolizers one month after RTx. P-values refer to the linear mixed model. Renal function in a 24 months follow-up (b). The differences between the follow-up eGFR values (month 2, 3, 6, 12, 24) and the eGFR value and the eGFR value at month 1 are shown for every metabolism group.
Table 3.
Renal function (linear mixed model).
Table 4.
Antibodies, HLA MM, DGF, infections and biopsy results.
Table 5.
Reasons for switching immunosuppression and adverse events.