Table 1.
Clinical signs and intestinal lesions in piglets inoculated with C. difficile and treated with anti-toxin antibodies.
Figure 1.
Concentrations of human monoclonal antibodies CDA1 and CDB1 in the intestinal contents and tissues.
Gnotobiotic piglets were inoculated with either pathogenic UK6 or nonpathogenic CD37 and treated systemically with human monoclonal anti-toxin antibodies against TcdA and TcdB (CDA1 and CDB1) 2 days following inoculation. A. CDA1 in intestinal contents B. CDA1 in intestinal tissues C. CDB1 in intestinal contents D. CDB1 in intestinal tissues. * p<0.05 between groups using the independent samples t-test. Bars represent the mean with standard error.
Figure 2.
Concentrations of human monoclonal antibodies CDA1 and CDB1 in the large intestinal contents and tissues over time following systemic administration in piglets inoculated with C. difficile.
Gnotobiotic piglets were inoculated with pathogenic C. difficile strain UK6 and then treated once systemically with human monoclonal anti-toxin antibodies against TcdA and TcdB (CDA1 and CDB1) 2 days following inoculation, at the onset of clinical signs. Piglets were euthanized and tissues collected 2, 3, or 4 days following antibody administration. A. CDA1 in large intestinal contents B. CDA1 in large intestinal tissues C. CDB1 in large intestinal contents D. CDB1 in large intestinal tissues. Bars represent the mean with standard error.