Table 1.
Clinical Characteristics and SD-OCT findings of Patients with AZOOR-Complex.
Figure 1.
Static visual field and spectral-domain optical coherence tomographic (SD-OCT) results of the right eye of Case 11 at the initial visit (A–C) and six months after the initial visit (D–F).
A: Deviation plot obtained by the Humphrey 30-2 program at the initial visit. B: Horizontal SD-OCT image through the fovea at the initial visit. C: Magnified view of the area outlined by dashed yellow line box in the image of B. D: Deviation plot obtained with the Humphrey 30-2 program at six months after the initial visit. E: Horizontal SD-OCT image through the fovea at six months after the initial visit. F: Magnified view of the area outlined by dashed yellow line box in the image of E. ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone. This case had the retinal area where the outer nuclear layer (ONL) was completely absent (red line boxes).
Figure 2.
Static visual field and spectral-domain optical coherence tomography (SD-OCT) results of the right eye of Case 1 at the initial visit (A–C) and six months after the initial visit (D–F).
A: Deviation plot obtained with the Humphrey 30-2 program at the initial visit. B: Horizontal SD-OCT image through the fovea at the initial visit. C: Magnified view of the area outlined by dashed yellow line box in B. D: Deviation plot obtained with the Humphrey 30-2 program at six months after the initial visit. E: Horizontal SD-OCT image through the fovea at six months after the initial visit. F: Magnified view of the area outlined by dashed yellow line box in the image of B. ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone. Several column-shaped highly reflective materials are seen at the outer retinal area of visual field defect at the initial visit (red arrows).
Figure 3.
Static visual field and spectral-domain optical coherence tomographic (SD-OCT) results in the right eye of Case 2 at the initial visit (A–C) and six months after the initial visit (D–F).
A: Deviation plot obtained with the Humphrey 30-2 program at the initial visit. B: Horizontal SD-OCT image through the fovea at the initial visit. C: Magnified view of the area outlined by dashed yellow line box in the image of B. D: Deviation plot obtained by the Humphrey 30-2 program at six months after the initial visit. E: Horizontal SD-OCT image through the fovea at six months after the initial visit. F: Magnified view of the area outlined by dashed yellow line box in the image of B. The COST line is still blurred near the fovea (red arrow). ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone.
Figure 4.
Results of longitudinal reflectivity profile (LRP) in the retina of Case 2.
A. Horizontal SD-OCT scan through the fovea at the initial visit. B. Magnified view of the area outlined by dashed white line box in the image of A. C. Longitudinal reflectivity profile (LRP) along the vertical line at 0.5 mm temporal from the foveola (red dotted line) at the initial visit. D. Horizontal SD-OCT scan through the fovea at six months after the initial visit. E. Magnified view of the area outlined by dashed white line box in the image of D at six months after the initial visit. F. Longitudinal reflectivity profile (LRP) along the vertical line at 0.5 mm temporal from the foveola (red dotted line) at six months after the initial visit. At the retinal area of 0.5 mm temporal from the foveola, IDZ was nearly undetectable at the initial visit, but the peak of IDZ was clearly detectable as a third highly reflective band at six month later (asterisk). ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone. RPE/Bruch, retinal pigment epithelium/Bruch's membrane complex. LRP, longitudinal reflectivity profile.
Figure 5.
Static visual field and spectral-domain optical coherence tomographic (SD-OCT) results in the right eye of Case 3 at the initial visit (A–C) and six months after the initial visit (D–F).
A: Deviation plot obtained by the Humphrey 30-2 program at the initial visit. B: Horizontal SD-OCT image through the fovea at the initial visit. C: Magnified view of the area outlined by dashed yellow line box in the image of B. D: Deviation plot obtained by the Humphrey 30-2 program at six months after the initial visit. E: Horizontal SD-OCT image through the fovea at six months after the initial visit. F: Magnified view of the area outlined by dashed yellow line box in the image of E. ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone.
Figure 6.
Summary of findings of the three highly reflective bands at the outer retina obtained by SD-OCT at the initial visit and six months later.
These three lines were divided into three types; “continuous”, “discontinuous” and “absent”. ELM, external limiting membrane. EZ, ellipsoid zone. IDZ, interdigitation zone.