Figure 1.
Example illustrating how the regions of interest (ROI) are defined one slice of the MRE magnitude image of patient #10: healthy tissue (yellow), tumor (black dotted line), perifocal margin (red dashed line), and edema (black solid line).
The green line demarcates the region chosen for homogeneous appearing matter (HAM).
Figure 2.
Anatomical T2-weighted images (T2w), MRE magnitude images, and 3DMMRE parameter maps (|G*| and φ) of 2 GB patients (upper row: patient #15, bottom row: patient #14, corresponding to the tables).
The selected regions of tumor (dotted lines) and edema (solid line in #15) were used for the parameter evaluation as given in Table 2. The region of HAM is indicated by the dashed line. The yellow arrows indicate compartments of soft tissue properties (low |G*|) but different dissipative behavior (φ) in both tumors. |G*| was scaled from 0 to 3 kPa, φ was scaled from 0 to 2.5 rad.
Table 1.
Patient data, morphological classification on the basis of conventional MRI, size, and location of all tumors included in this study.
Table 2.
|G*| and φ values of the selected regions of interest (ROIs) as well as the parameter ratios of tumor ROI to healthy tissue ROI (normal appearing white matter) of the 22 patients included in the study.
Figure 3.
Viscoelastic properties of GB based on the parameter ratios of |G*| and φ between tumor and healthy reference tissue (ref).
Numbers correspond to the list of tumors in tables 1 and 2. For illustration purposes, standard deviations (SD) indicating intratumoral heterogeneity are shown for the two tumors presented in figure 2 (solid lines in 14, and 15). All SD values are given in table 2.