Figure 1.
Flow diagram of study selection.
Table 1.
Studies included in the systematic review and in the meta-analysis.
Figure 2.
Forest plot of the mean difference of LINE-1 methylation levels between cancer and control groups in tissue and blood samples.
Subgroup analysis based on sample type.
Figure 3.
Forest plot of the mean difference of LINE-1 methylation levels between cancer and control groups in tissue samples.
Subgroups analysis based on sample source.
Figure 4.
Forest plot of the mean difference of LINE-1 methylation levels between cancer and control groups.
Subgroups analysis based on cancer type.
Figure 5.
Forest plot of the mean difference of LINE-1 methylation levels between cancer and control groups.
Subgroups analysis based on method.
Figure 6.
Forest plot of the mean difference of LINE-1 methylation levels between cancer and control groups in tissue samples.
Subgroups analysis based on method.
Figure 7.
Subgroup analysis based on sample type.
Figure 8.
Subgroup analysis based on tissue specimen types. SE, standard error, MD, mean difference.
Figure 9.
Subgroup analysis based on cancer type in blood samples.
Figure 10.
Subgroup analysis based on cancer type in tissue samples.
Figure 11.
Subgroup analysis based on detection method in blood samples.
Figure 12.
Subgroup analysis based on detection method in tissue samples.