Figure 1.
MRI template and maximum probability atlas creation procedures.
(A) Creation of the MRI template from N individual MRIs. (B) Creation of a maximum probability atlas from a database of N individual label volumes, associated to the N MRIs.
Table 1.
Anatomical regions of the digital atlases.
Figure 2.
Multi-atlas segmentation methods.
MP method (A) using one maximum probability atlas previously created in a template space. PF method (B) using a multi-atlas dataset, and creating an ad-hoc maximum probability atlas in the target space.
Figure 3.
Multi-atlas dataset and maximum probability atlas.
Rat MRI template (A) composed from 7 individuals. Dataset of 7 individual atlases (B). Maximum probability atlas (C), combination of the 7 individual atlases. Coronal slices, 2 mm apart (one slice out of five are shown).
Table 2.
Morphometric evaluation.
Figure 4.
Application for functional measure automated extraction.
Regression graphs of [18F]FDG regional standard uptake values (SUVs) obtained with automated segmentation methods, compared to SUVs obtained with manual segmentation. (A) SA method, (B) MP method performed with direct registration of the PET image to the template MRI, (C) MP method, (D) PF method.
Table 3.
Functional evaluation: regression against extraction with manual atlas.