Figure 1.
Morphology of CIN grades and normal epithelium.
All samples are Haematoxylin-Eosin (H&E) stained and digitally scanned at a magnification of 40. Boxes show witch area to focus on. (A) Atypical cells in the first third are typically for CIN 1. (B) CIN 2 contains atypical cells in the lower two thirds of the epithelium. (C) If the whole epithelium is covered by atypical cells, the grade is called CIN 3. (D) Atypical cells are missing in normal epithelium.
Figure 2.
The use of RGB relative makes nuclei appearing blue (A).
B shows the same image having set blue to white and all other pixels to black. The picture containing blobs (C) can be improved by erasing them to focus on the nuclei (D).
Figure 3.
Relation between grades of neoplasia and normal epithelium.
(A) Multifractal spectra and (B) Box plots of box counting dimension dBOX.
Table 1.
Detailed values of fractal dimensions as well as the calculated values of minimum, maximum and median.
Table 2.
Confusion matrix comparing pathologist's results for CIN 1, CIN 2, CIN 3 and predicted group by box counting dimension dBOX.
Figure 4.
High grade and low grade neoplasia.
(A) Multifractal spectra. Error bars represent standard errors of mean. (B) Box plots of box counting dimension dBOX.
Table 3.
Confusion matrix comparing pathologist's results for low-grade and high grade neoplasia and predicted group by box counting dimension dBOX.