Table 1.
Demographic and clinical characteristics of the PD and HC groups.
Figure 1.
Schematic illustration of analysis.
We first constructed functional connectivity network (step A–D) within the CBG motor network (A) at voxel-wise scale (B), and optimal sparsity threshold was estimated and applied (D). Once network was constructed, efficiency for each node was computed and efficiency map for each subject was generated (E).
Figure 2.
Brain regions with blue color indicated significant (FDR multiple comparison correction, p<0.05) decreases of efficiency map in PD relative to healthy control using two-tailed two sample t test with age, gender and frame-wise displacement as covariance.
Those regions were presented in axial view. HC, healthy control; PD, Parkinson's disease.
Table 2.
Brain regions showing marked difference of efficiency between PD and HC.
Figure 3.
Association of UPDRS motor score with nodal efficiency value in brain areas obtained from comparison of efficiency map between the two groups.
UPDRS motor score was significantly correlated with efficiency value in the left M1, right pre-SMA, bilateral GP and THA (p<0.05). The rs donates the spearman correlation coefficient. M1, primary motor cortex; pre-SMA, pre-supplementary motor area; GP, globus pallidus; THA, thalamus.