Table 1.
Number of all removed lymph nodes identified on histopathologic specimens.
Table 2.
Sensitivity and specificity at each PJY10 dosage.
Table 3.
Quantitative analysis: signal intensity difference between the benign and metastatic lymph nodes at different PJY10 dosages.
Table 4.
Quantitative analysis: Az values with regard to diagnosing lymph node metastasis at different PJY10 dosages.
Figure 1.
Linear regression plots between histopathologic area ratio (Arearatio) and quantitative image analysis parameters.
The best-fit lines (ie, the graphs of the linear regression equations) are shown as solid lines for linear regression analyses between the Arearatio and either the number of voxels[low] (A) or the mean signal intensity (SI) ratio (B) at PJY10 dosage of 10.4 mg Fe/kg. The curves above and below the best-fit line represent the upper and lower bounds of the 95% confidence interval (CI). r = correlation coefficient.
Figure 2.
A tumor model into which 10.4 mg Fe/kg of PJY10 was administered.
(A, B) An ovoid right common iliac lymph node with a short-axis diameter of 0.3 cm shows a focal signal drop at its superior aspect (arrow) on the postcontrast coronal T2*-weighted MR image (B), as compared with the precontrast image (A). (C) The hematoxylin-eosin (H-E) stained pathology specimen at high-power field (magnification×400) well-demonstrates a metastatic focus (arrowheads) at the inferior aspect of the lymph node, corresponding to the portion with no signal drop on the postcontrast MR image (B). (D, E) Another enlarged lymph node (arrow) at the iliac bifurcation remains unchanged on the postcontrast coronal T2*-weighted MR image (E), as compared with the precontrast image (D). (Some susceptibility artifact due to adjacent bowel gas is present on the precontrast image.) (F) Multiple metastatic foci (arrowheads) were confirmed on the hematoxylin-eosin (H-E) stained pathology specimen (magnification×400).
Figure 3.
An inflammation model into which 10.4 mg Fe/kg of PJY10 was administered.
(A, B) The pre- (A) and postcontrast (B) coronal T2*-weighted MR images demonstrate a central darkening of an enlarged lymph node (arrow) in the right common iliac area. (C) An electron microscopy image of the lymph node confirmed the presence of contrast particles (arrowheads) within the cytoplasmic organelle of the lymph node macrophage (magnification×20,000).