Table 1.
Age (days) and weight (kg) of LQT1 and LMC rabbits.
Figure 1.
Baseline ECG and monophasic action potentials (MAP) in LQT1 and LMC rabbits.
Exemplary representative baseline ECG (lead II) of (A) LQT1 and (B) LMC rabbit, QT and RR intervals are delineated. (C) Exemplary MAP of LQT1 and LMC rabbit at baseline. (D) APD in LQT1 (n = 18) vs. in LMC (n = 14) rabbits at baseline. t = trend (p<0.1), *p<0.05, **p<0.01.
Figure 2.
Erythromycin-induced prolongation of APD and in LQT1 and LMC rabbits.
Exemplary, representative MAP in (A) LQT1 and (B) LMC rabbit at baseline and at different concentrations of erythromycin. Percentaged prolongation of APD related to baseline APD (%APD) in LQT1 (n = 9) and LMC (n = 7) rabbits in (C) LV apex, (D) LV mid, (E) LV base-lateral and (F) RV mid positions during perfusion with increasing concentrations of erythromycin. t = trend (p<0.1), *p<0.05.
Figure 3.
E-4031-induced prolongation of APD in LQT1 and LMC rabbits.
Exemplary, representative MAP in (A) LQT1 and (B) LMC rabbits at baseline and at different concentrations of E-4031. Percentaged prolongation of APD related to baseline APD (%APD) in LQT1 (n = 9) and LMC (n = 7) rabbits in (C) LV apex, (D) LV mid, (E) LV base-lateral, and (F) RV mid position during perfusion with increasing concentrations of E-4031. *p<0.05.
Figure 4.
Spatial dispersion of action potential duration in LQT1 and LMC rabbits.
Differences of spatial dispersion of action potential duration (APD75) between LQT1 (n = 9 for erythromycin, n = 8 for E-4031) and LMC (n = 7 each) rabbits at baseline and during perfusion with erythromycin (A–C) or E-4031 (D–F). t = trend (p<0.1), *p<0.05, **p<0.01.
Figure 5.
Erythromycin-induced changes in triangulation of monophasic action potential in LQT1 and LMC rabbits.
Exemplary, representative MAP triangulation in (A) LQT1 and LMC rabbit at baseline. Exemplary, representative MAP triangulation in (B) LQT1 rabbit and (C) LMC rabbit at baseline and during 300 µM erythromycin. Triangulation of MAP at increasing concentrations of erythromycin in LQT1 (n = 9) and LMC (n = 7) rabbits in (D) LV apex, (E) LV mid, (F) LV base septal, and (G) RV mid position. t = trend (p<0.1), *p<0.05, **p<0.01.
Figure 6.
E-4031-induced triangulation of monophasic action potential in LQT1 and LMC rabbits.
Exemplary, representative MAP triangulation in (A) LQT1 and LMC rabbit at baseline. Exemplary, representative MAP triangulation in (B) LQT1 rabbit and (C) LMC rabbit at baseline and during 0.1 µM E-4031. Triangulation of MAP at increasing concentrations of E-4031 in LQT1 (n = 9) and LMC (n = 6) rabbits in (D) LV apex, (E) LV mid, (F) LV base-septal, and (G) RV mid positions. t = trend (p<0.1), *p<0.05, **p<0.01.