Figure 1.
Flow diagram graphically describes the design of the study: enrollment, intervention, follow-up and data analysis.
Table 1.
Between-group comparison for right posterior insula for the contrast T1>T0.
Figure 2.
Insula functional connectivity patterns before drug/placebo treatment.
Image depicts functional connectivity patterns of the four subregions of bilateral insulae as assessed with rs-fMRI. Maps are overimposed on a Talairach atlas and in radiological convention with a statistical significance set at p<0.05 Bonferroni corrected. AIlh = anterior insula left hemisphere; AIrh = anterior insula right hemphere; Pilh = posterior insula left hemisphere; PIrh = posterior insula right hemisphere.
Figure 3.
Between-group comparison of the right posterior insula pattern before and after drug/placebo treatment.
Image depicts the map obtained after contrast T1 (drug>placebo) >T0 (drug>placebo) for the right posterior insula (PIrh). The map is overimposed on a Talairach atlas and in radiological convention (p<0.02 FDR corrected). Differences are assessed by means of a mixed model voxel wise ANOVA with a between-group factor (Drug vs Placebo) and a repeated measure factor (T0 vs. T1).
Figure 4.
Between-group comparison of the four insula subregions before drug/placebo treatment.
Image depicts maps obtained after contrast T0 (Drug>Placebo) for the four subregions of bilateral insulae as assessed with rs-fMRI. Maps are overimposed on a Talairach atlas and in radiological convention (p<0.02 FDR corrected). Differences are assessed by means of a mixed model voxel wise ANOVA with a between-group factor (Drug vs Placebo) and a repeated measure factor (T0 vs. T1) and specific contrast T0 (Drug>Placebo). AIlh = anterior insula left hemisphere; AIrh = anterior insula right hemphere; Pilh = posterior insula left hemisphere; PIrh = posterior insula right hemisphere.
Table 2.
Insula subregional seed-based correlation.
Figure 5.
Insula functional connectivity patterns after drug/placebo treatment.
Image depicts functional connectivity patterns of the four subregions of bilateral insulae as assessed with rs-fMRI. Maps are overimposed on a Talairach atlas and in radiological convention with a statistical significance of p<0.05 Bonferroni corrected. AIlh = anterior insula left hemisphere; AIrh = anterior insula right hemphere; Pilh = posterior insula left hemisphere; PIrh = posterior insula right hemisphere.