Table 1.
Patient and sample characteristics.
Figure 1.
Cytopathology and histopathology analysis of EBUS-TBNA diagnostic and research specimens and derivative xenograft.
Scale bar = 30 µm. H&E = haemotoxylin and eosin stain. Blank squares indicate that the sample was not available.
Figure 2.
Immunohistochemical analysis of EBUS-TBNA diagnostic and research specimens and derivative xenografts.
Scale bar = 30 µm. Blank squares indicate that the sample was not available.
Figure 3.
Features of specimen LX104 and its derivative xenograft.
A. Diff-Quick stained cytology smear of diagnostic EBUS-TBNA sample. Scale bar = 15 µm. B. Diff-Quick stained cytology smear of experimental EBUS-TBNA sample. Scale bar = 15 µm. C. Haematoxylin and eosin stained section of the diagnostic cell block. Scale bar = 30 µm. D. Diagnostic cell block stained for CD56. Scale bar = 30 µm. E. Haematoxylin and eosin stained section of the derivative xenograft. Scale bar = 300 µm. F. Haematoxylin and eosin stained section of the derivative xenograft. Scale bar = 30 µm. G. Section of the derivative xenograft stained for CD56. Scale bar = 30 µm. H. Section of the derivative xenograft stained for TTF1. Scale bar = 30 µm.
Table 2.
Research sample and PDX characteristics.
Table 3.
Variants detected in primary samples derivative xenografts.
Figure 4.
Ideogram summarising variants predicted to result in mutations commonly seen in SCLC.
Genes are ranked by % according to their prevalence in the COSMIC database. Mutations detected in both the primary sample and the xenograft are shown.