Figure 1.
Identification process for eligible studies.
Of the 296 studies initially identified from our electronic search, 16 met the inclusion criteria and were included in this meta-analysis.
Table 1.
Characteristics of the studies included in the meta-analysis of the prognostic value of NSE in patients with traumatic brain injury.
Figure 2.
Risk of bias and applicability concerns of included studies examining role of NSE concentrations in prognosis in patients with traumatic brain injury.
Figure 3.
Association between NSE (shown as mean (SD) in transformed concentration) and mortality in patients with traumatic brain injury.
Figure 4.
Association between NSE (shown as mean (SD) in transformed concentration) and unfavourable outcome in patients with traumatic brain injury.
Figure 5.
Funnel plot for the studies included to analysis the association between NSE concentration and mortality in patients with traumatic brain injury.
Figure 6.
Funnel plot for the studies included to analysis the association between NSE concentration and unfavourable outcome in patients with traumatic brain injury.
Table 2.
Sensitivity analyses for association of NSE concentrations with mortality in patients with traumatic brain injury.
Table 3.
Sensitivity analyses for association of NSE concentrations with unfavourable outcome in patients with traumatic brain injury.
Figure 7.
The pooled sensitivity and specificity to predict unfavourable outcome in patients with traumatic brain injury.
Figure 8.
The pooled sensitivity and specificity to predict mortality in patients with traumatic brain injury.
Figure 9.
The pooled positive predictive value (PPV) and negative predictive value (NPV) to predict mortality in patients with traumatic brain injury.
Figure 10.
The pooled positive predictive value (PPV) and negative predictive value (NPV) to predict unfavourable outcome in patients with traumatic brain injury.
Figure 11.
The hierarchical summary receiver operating characteristic (HSROC) curves of NSE to predict mortality in patients with traumatic brain injury.
Figure 12.
The hierarchical summary receiver operating characteristic (HSROC) curves of NSE to predict unfavourable outcome in patients with traumatic brain injury.
Table 4.
Sensitivity analyses for the sensitivity and specificity of NSE concentrations to predict the mortality in patients with traumatic brain injury.
Table 5.
Sensitivity analyses for the sensitivity and specificity of NSE concentrations to predict unfavourable outcome in patients with traumatic brain injury.